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auricula-judae extracts show strong antioxidant properties with a positive correlation between levels of phenols and antioxidant capacity 7-9.ĪNTI-THROMBOTIC – Polysaccharide extracts of A. auricula-judae’s traditional use for soothing irritated or inflamed mucous membranes 6.ĪNTIOXIDANT – A. auricula-judae polysaccharides have anti-inflammatory activity, which correlates with A. auricula-judae is of particular interest as a functional food for the elderly, with polysaccharide extracts showing considerable promise and Auricularia polytricha in processed and unprocessed form exhibiting inhibitory activity against one of the key enzymes involved in Alzheimer’s disease 4,5.ĪNTI-INFLAMMATORY – A. auricula-judae fruiting bodies contain high levels of polysaccharides and these are the main bioactive component, although phenols have been shown to contribute to the total antioxidant and hypercholesterolaemic activity 2,3.Ī. polytricha (Mao Mu Er ‘Hairy Wood Ear’, or Yun Er ‘Cloud Ear’) are considered as species of Mu Er in Chinese medicine and today are used interchangeably 1.
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A type of jelly fungus, it produces fruiting bodies that are translucent, brown in colour and ‘ear’ shaped, hence its Chinese name ‘Wood Ear’. In conclusion,the current study revealed the previously unknown effect of dichloromethane ethyl extract of Auricularia auricula-judae inhibitions of the production of NO, IL-6, TNF-α and IL-1β in LPS-stimulated macrophages.Auricularia auricula-judae grows throughout Europe, Asia and the United States and is highly valued in Asian cooking for its crunchy, rubbery texture. The inhibition of IL-1β cytokine at protein level was also observed in a dose dependent manner. Nevertheless, dichloromethane extract of Auricularia auricula-judae did not show complete inhibition of IL-6 mRNA expression. Furthermore, RT-PCR results of this study indicated that the extract markedly reduced the expressions of inflammatory cytokines (IL-6, TNF-α and IL-1β) mRNA in LPS-treated murine RAW 264.7 macrophages, which could possibly ameliorate the inflammation. Dichloromethane extract of Auricularia auricula-judae inhibited Lipopolysaccharide (LPS)-induced nitric oxide (NO) production significantly in a dose dependent manner in the concentration ≥ 10 μg/ml (p < 0.05). TI - Anti-inflammatory Activity of Dichloromethane Extract of Auricularia auricula-judae in RAW264.7 CellsĪB - The present study investigated the anti-inflammatory effects of dichloromethane extract of Auricularia auricula-judae. In conclusion,the current study revealed the previously unknown effect of dichloromethane ethyl extract of Auricularia auricula-judae inhibitions of the production of NO, IL-6, TNF-α and IL-1β in LPS-stimulated macrophages. The present study investigated the anti-inflammatory effects of dichloromethane extract of Auricularia auricula-judae.